Postdoctoral Associate (44115)
My NCBI Collections (Abranches)MINIMUM REQUIREMENTS:Applicants should have earned a PhD, or PhD along with a DMD/DDS,MD, or DVM degree by time of hire.PREFERRED QUALIFICATIONS:Individuals with expertise in bacterial genetics and geneexpression; genome-scale analysis of the microbiome; microbialpathogenesis; host:microbiome interactions; microbial biofilms;bioinformatics; interbacterial interactions; protein translocationand structural biology; diabetes; chronic inflammation; and/or hostresponses to pathogenic, commensal and beneficial microorganismsare sought.Applicants should submit a cover letter, CV, and the names andcontact information for three references. Final candidate will berequired to provide official transcript to the hiring departmentupon hire. A transcript will not be considered “official” if adesignation of “Issued to Student” is visible. Degrees earned froman education institution outside of the United States are requiredto be evaluated by a professional credentialing service providerapproved by National Association of Credential Evaluation Services(NACES) which can be found at http://www.naces.org/ .HEALTH ASSESSMENT REQUIRED UPON HIREAll candidates for employment are subject to a pre-employmentscreening which includes a review of criminal records, referencechecks, and verification of education.If an accommodation due to a disability is needed to apply for thisposition, please call 352-392-2477 or the Florida Relay System at800-955-8771 (TDD). Hiring is contingent upon eligibility to workin the US. Searches are conducted in accordance with Florida’sSunshine Law.The University of Florida is committed to non-discrimination withrespect to race, creed, color, religion, age, disability, sex,sexual orientation, gender identity and expression, marital status,national origin, political opinions or affiliations, geneticinformation and veteran status in all aspects of employmentincluding recruitment, hiring, promotions, transfers, discipline,terminations, wage and salary administration, benefits, andtraining. THE REVIEW OF APPLICATIONS WILL BEGIN IMMEDIATELY AND WILL CONTINUEUNTIL ALL POSITIONS ARE FILLED. THE UNIVERSITY OF FLORIDA IS ANEQUAL OPPORTUNITY INSTITUTION DEDICATED TO BUILDING A BROADLYDIVERSE AND INCLUSIVE WORK ENVIRONMENT. My NCBI Collections POSTDOCTORAL POSITIONS AVAILABLEMultiple postdoctoral positions are available in the Department ofOral Biology in the College of Dentistry as noted below. Applicantsshould have earned a PhD, or PhD along with a DMD/DDS, MD, or DVMdegree, by time of hire. For details on faculty mentors andprojects, please visit: https://dental.ufl.edu/departments/oral-biology/ LABORATORY OF DR. JACQUELINE ABRANCHESThe Lemos-Abranches lab uses genetics, biochemistry, transcriptomicand metabolomics approaches to characterize the molecular factorsthat mediate virulence in opportunistic Grampositive pathogens suchas Streptococcus mutans and Enterococcus faecalis. In S. mutans, amajor pathogen in dental caries and a leading causative agent ofinfective endocarditis, our current efforts focus on thecharacterization of the oxidative stress regulator Spx and its rolein controlling stress responses and biofilm formation. The secondS. mutans project focuses on the characterization of a collagenbinding protein responsible for intracellular invasion of heart andoral tissues, a trait that is linked to increased virulence and,potentially, recurrent infection and chronic inflammation. Thecharacterization of stress responses is also the theme of ourresearch with E. faecalis, a leading cause of hospital-acquiredinfections. In this project, we are investigating the interplaybetween the stringent response, a major bacterial stress responsemechanism for adaptation to changing environments, with otherprominent stress regulators and how these interactions influencethe ability of E. faecalis to survive antibiotic stress and otheradverse conditions. LABORATORY OF DR. MARY ELLEN DAVEYThe Davey lab uses a combination of genetics, bacterial physiology,and gene expression analysis (RNA-seq and qPCR) to study theinterrelationship between biofilm development and the pathogenicityof the oral anaerobe, Porphyromonas gingivalis. Inparticular, we are focused on molecular mechanisms that controlchanges in expression of cell surface structures, includingcapsular polysaccharides, sphingolipids, and fimbriae; and thesubsequent impact on the interaction of P. gingivalis withhost cells. (Project numbers: 2 R01 DE019117 07; and 1 R01 DE02458001A1) LABORATORY OF DR. JOSE LEMOS LABORATORY OF DR. L. JEANNINE BRADYWork in the Brady Lab is directed at understanding mechanisms ofmembrane and cell surface biogenesis in the cariogenic pathogenStreptococcus mutans. The functional interactions and respectiveroles of components of the co-translational signal recognitionparticle (SRP) pathway and the YidC1 and YidC2 chaperone-insertasesin membrane protein insertion are being evaluated with an emphasison competence development and mutacin production. In addition, S.mutans has been found to produce functional amyloids that influencebiofilm development and that can serve as targets for therapeuticanti-amyloid compounds. Study is currently directed at elucidatingthe structural basis and environmental control of amyloidfibrillization in in vitro and in vivo systems. Furthermore, S.mutans is capable of releasing DNA into the extracellularenvironment via membrane vesicles. The contribution ofvesicle-released eDNA to biofilm formation and its functionalinteractions with bacterial cells and extracellular matrixcomponents are under study.Post-doctoral candidates will be considered to evaluate developmentand stabilization of biofilm matrices related to amyloid formationand should have demonstrated expertise in the characterization ofprotein-protein and protein-nucleic acid interactions, in proteinstructure analysis, particularly by solid state NMR, and/or inelectron and confocal microscopy.MyNCBI Collections My NCBI Collections My NCBI Collections (Lemos) LABORATORY OF DR. ROBERT A. BURNEMultiple postdoctoral positions are available to study generegulation, genomics and physiology of pathogenic, commensal and/orbeneficial oral streptococci. Projects include use of planktonic,biofilm, and microfluidic model systems to analyze modulation ofintercellular communication systems by peptides and other smalleffector molecules, and by environmental inputs that include pH,carbohydrate source and oxygen. Other projects involve explorationof the genetic and genomic basis for expression by commensal oralstreptococci of properties that are beneficial to their host andantagonistic to pathogenic species.