The science of siestas
Sleep test predicts dementia in older adults MGH research finds chemical pathway from lack of shut-eye to atherosclerosis How often a person takes daytime naps, if at all, is partly regulated by their genes, according to new research led by investigators at Harvard-affiliated Massachusetts General Hospital (MGH) and published in Nature Communications.In this study, the largest of its kind ever conducted, the MGH team collaborated with colleagues at the University of Murcia in Spain and several other institutions to identify dozens of gene regions that govern the tendency to take naps during the day. They also uncovered preliminary evidence linking napping habits to cardiometabolic health.“Napping is somewhat controversial,” says Hassan Saeed Dashti of the MGH Center for Genomic Medicine, co-lead author of the report with Iyas Daghlas, a medical student at Harvard Medical School (HMS). Dashti notes that some countries where daytime naps have long been part of the culture (such as Spain) now discourage the habit. Meanwhile, some companies in the United States now promote napping as a way to boost productivity. “It was important to try to disentangle the biological pathways that contribute to why we nap,” says Dashti.Previously, co-senior author Richa Saxena, principal investigator at the Saxena Lab at MGH, and her colleagues used massive databases of genetic and lifestyle information to study other aspects of sleep. Notably, the team has identified genes associated with sleep duration, insomnia, and the tendency to be an early riser or “night owl.” To gain a better understanding of the genetics of napping, Saxena’s team and co-senior author Marta Garaulet of the department of physiology at the University of Murcia, performed a genome-wide association study (GWAS), which involves rapid scanning of complete sets of DNA, or genomes, of a large number of people. The goal of a GWAS is to identify genetic variations that are associated with a specific disease or, in this case, habit.For this study, the MGH researchers and their colleagues used data from the UK Biobank, which includes genetic information from 452,633 people. All participants were asked whether they nap during the day “never/rarely,” “sometimes” or “usually.” The GWAS identified 123 regions in the human genome that are associated with daytime napping. A subset of participants wore activity monitors called accelerometers, which provide data about daytime sedentary behavior, which can be an indicator of napping. This objective data indicated that the self-reports about napping were accurate. “That gave an extra layer of confidence that what we found is real and not an artifact,” says Dashti.Several other features of the study bolster its results. For example, the researchers independently replicated their findings in an analysis of the genomes of 541,333 people collected by 23andMe, the consumer genetic-testing company. Also, a significant number of the genes near or at regions identified by the GWAS are already known to play a role in sleep. One example is KSR2, a gene that the MGH team and collaborators had previously found plays a role in sleep regulation.Digging deeper into the data, the team identified at least three potential mechanisms that promote napping:Sleep propensity: Some people need more shut-eye than others.Disrupted sleep: A daytime nap can help make up for poor quality slumber the night before.Early morning awakening: People who rise early may “catch up” on sleep with a nap.“This tells us that daytime napping is biologically driven and not just an environmental or behavioral choice,” says Dashti. Sleep, heart disease link leads from brain to marrow Some of these subtypes were linked to cardiometabolic health concerns, such as large waist circumference and elevated blood pressure, though more research on those associations is needed.“Future work may help to develop personalized recommendations for siesta,” says Garaulet.Furthermore, several gene variants linked to napping were already associated with signaling by a neuropeptide called orexin, which plays a role in wakefulness. “This pathway is known to be involved in rare sleep disorders like narcolepsy, but our findings show that smaller perturbations in the pathway can explain why some people nap more than others,” says Daghlas.Saxena is the Phyllis and Jerome Lyle Rappaport MGH Research Scholar at the Center for Genomic Medicine and an associate professor of anesthesia at HMS.The work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases, the National Heart, Lung, and Blood Institute, MGH Research Scholar Fund, Spanish Government of Investigation, Development and Innovation, the Autonomous Community of the Region of Murcia through the Seneca Foundation, Academy of Finland, Instrumentarium Science Foundation, Yrjö Jahnsson Foundation, and Medical Research Council. Related Study identifies gene regions associated with sleep duration Both too much and too little shut-eye can be associated with health problems Measurements of brain activity during sleep reveal signs of accelerated brain aging
Chalet on the hill for sale
A QUIRKY Castle Hill home complete with ocean views has come on to the market for the first time in 24 years.6 Cottesmore Crescent in Castle Hill will be sold at auction on October 2.It has four bedrooms, two bathroom, two car spaces and is on a 772 sqm elevated block of and.Located in Townsville’s most expensive suburb the home has ocean views, cool breezes and is only minutes away from The Strand and some of the city’s best schools.The has vaulted, beamed ceilings and a charming front veranda reminiscent of a mountain chalet. 6 Cottesmore Cres, Castle HillRay White Julie Mahoney owner Julie Mahoney said the owner was sad to be leaving her home after more than two decades living there but needed to downsize.“It has an original and immaculate construction that has survived many cyclones including Yasi,” she said.“Each person that has come through the home knows that it is a Tomi home.“It has beautiful views and a wonderful sea breeze that flows through the home.”More from news01:21Buyer demand explodes in Townsville’s 2019 flood-affected suburbs12 Sep 202001:21‘Giant surge’ in new home sales lifts Townsville property market10 Sep 2020The house has been immaculately maintained during the past 24 years and still has the original kitchen which has ocean views. 6 Cottesmore Cres, Castle Hill“It is an ideal entry level home to Castle Hill Hill,” she said.“it is mainly single level with dual car access.“It is a beautifully established home with well maintained gardens and it has fabulous neighbours making it a great long-term residence. 6 Cottesmore Cres, Castle HillThe living area is open and airy flowing on the front patio.The master bedroom has an ensuite and built-in wardrobe and also has ocean views while the remaining three bedrooms also have built in hair wardrobes.The partially covered front patio is spacious and cool with access tot he gardens as well as views of Castle Hill, the city and the ocean.The dual carport also has an attached shed with laundry.Ms Mahoney said it would be an ideal home for someone keen to buy into the suburb of Castle Hill.
Inter Milan, Lazio still going for Chelsea forward
Loading… Inter, Lazio and Tottenham Hotspur have reportedly not given up on Olivier Giroud even after his Chelsea contract extension.Advertisement Promoted Content8 Fascinating Facts About Coffee12 Actors Who Can Only Play Bad GuysCouples Who Celebrated Their Union In A Unique, Unforgettable WayThe Very Last Bitcoin Will Be Mined Around 2140. Read MoreBest Car Manufacturers In The WorldWho Is The Most Powerful Woman On Earth?13 kids at weddings who just don’t give a hoot2020 Tattoo Trends: Here’s What You’ll See This Year7 Universities Where Getting An Education Costs A Hefty PennyInsane 3D Spraying Skills Turn In Incredible Street Art6 Ridiculous Health Myths That Are Actually TrueWhat Happens To Your Brain When You Play Too Much Video Games? The forward was going to be a free agent this summer and was very close to Inter in the January transfer window.According to the Daily Express, signing a new one-year deal at Stamford Bridge has by no means secured his future, it just guaranteed Chelsea won’t lose him as a free agent.Inter and Lazio are still ready to pursue the 33-year-old France international.Read Also: Premier League: One positive case in latest round of testingThey are joined in the race by Jose Mourinho’s Tottenham Hotspur, which would mean his family didn’t have to leave London.Lazio director Igli Tare visited Giroud in January and said recently he had got the idea the player wanted to remain in the English Capital, as his family has been there since the move to Arsenal in 2012.FacebookTwitterWhatsAppEmail分享
MBB : Syracuse ties best start in school history with win
Facebook Twitter Google+ Comments Published on January 14, 2012 at 12:00 pm Contact Mark: [email protected] | @mark_cooperjr Nineteen wins into the season, Syracuse is still focused.The Orange matched a record set by the 1999-00 team for the best start to a season in school history with Saturday’s 78-55 win over Providence. SU is also the only team that is undefeated in Big East play. But SU head coach Jim Boeheim said the team is still as focused as it was for the season opener, which has so far prevented any slip-ups.‘We’re just trying to get ready for the next game and that’s all we’ve thought about and that’s all we’ll keep doing,’ Boeheim said. ‘That’s just the only way to approach basketball games. You don’t get ready, you’re going to get beat.‘We just got to get ready every night. Watching games today, a couple teams didn’t get ready, they got beat. Simple as that.’If SU beats Pittsburgh in its next game on Monday, it will also be a giant step for Boeheim in the college coaching records. Boeheim won his 875th career game Saturday and is one win shy of tying Adolph Rupp for fourth all-time among Division-I head coaches.AdvertisementThis is placeholder textSyracuse dismantled a Friars team that was coming off a 31-point win over No. 14 Louisville. Providence was missing its leading scorer, Vincent Council, but the Orange once again showed no signs of weakness.Dion Waiters said that SU has had its lapses. Against Marquette, the Orange led by 18 at halftime and let the Golden Eagles come back and nearly take the lead in the second half.Fortunately, the SU guard said, Syracuse has still managed to win those games and learn from them. The Orange has stayed undefeated and hasn’t let the No. 1 ranking affect its play.‘We’ve been trying to get better every game,’ SU guard Scoop Jardine said. ‘Never beating ourselves and always focusing on that game right there that we’re about to be in.’The Orange faces Pittsburgh on Monday. The Panthers dealt SU its first loss of last season, spurring a four-game losing streak that put a damper on Syracuse’s 18-0 start.SU forward Kris Joseph said that if and when the Orange falls for the first time, he will make sure a losing streak doesn’t follow.‘That will definitely be something that we’re going to be reminded of,’ Joseph said, ‘and I’m sure I’ll voice my opinion on that and Scoop will do the same so we won’t let that happen.‘For now, we’re enjoying the win streak.’[email protected]