Notre Dame receives record-breaking research grant for disease prevention
Notre Dame recently received a record-breaking grant of $33.7 million to conduct research on the prevention of mosquito-borne diseases using a new spatial repellent product that works to reduce mosquito densities and fight diseases like malaria, dengue, Zika and chikungunya. Unitaid, an international health organization, agreed to fund the five-year project after a long and competitive proposal process. For the scientists behind the project, though, the amount of money was not of primary importance.“We like to focus on the impact of the science rather than the monetary value,” the project’s principal investigator, John Grieco, said. “The value is something the University looks at. For us, it’s more the impact we’re having on human health. When you work alongside these communities and individuals, you see the struggles that they have day-to-day. If we can see a product through to reduce disease in these communities, that’s the success for us.”Notre Dame Research, the central department that oversees infrastructure and management for student and faculty research on campus, has been particularly involved in this project due to the magnitude of the grant. “Dr. Grieco came to us right away and said, ‘This is going to be big,’” vice president of research Robert Bernhard said. “You could see in the announcement that they were looking for some pretty sophisticated project management.”Grieco and his team continued to work with Unitaid during a 19-month proposal process, one of the longest he has ever been through, he said. However, his work with spatial repellent products has spanned much longer. Grieco and Nicole Achee, a medical entomologist who serves as the scientific director of the project, have been working on developing spatial repellent products for over two decades.The process began when Achee was invited to speak about spatial repellent research at a conference in Madrid, Grieco said. Funding representatives from Unitaid were present in the audience, and when Unitaid sent out a general call for proposals, several people from the organization were already familiar with their work. Though this didn’t guarantee a grant, Grieco said it was certainly an advantage.“When we first started working with spatial repellents, people thought there was no such thing,” Grieco said. “It’s been a long process on getting recognition that they actually have a function in reducing vector-borne disease. Now, we’re trying to have the World Health Organization formally recognize the utility of spatial repellents for use against malaria and other vector-borne diseases.”In order to receive the World Health Organization’s formal recognition, Grieco and his team must conduct clinical trials and operational studies. The clinical trials, which will take place in controlled environments in Kenya and Sri Lanka, will examine the effectiveness of the spatial repellent product over a period of one to two years, Achee said. “We’re not trying to make a better product, we’re trying to make a product to help existing tools,” she said. “In some settings, it could be that the spatial repellent is the only product used, or it could be added onto existing strategies.”The product could be especially effective in places where the spread of vector-borne diseases is difficult to prevent using current methods, including refugee camps, where many people live in tents or three-walled structures.Achee said after the clinical trials, the team will conduct operational studies in displaced persons camps in Mali and Uganda to determine the effectiveness of different distribution methods for the product. “We need an understanding of how well it works in a real-world setting,” Achee said. “We’re looking at how to distribute products to achieve the greatest coverage, and how many products can be distributed over what period of time [and] to how many people.”While developing and researching their product, Grieco and his team have found some unexpected results that contribute toward their ultimate goal of reducing vector-borne diseases.“The more we study them, the harder it becomes for us to narrow down what the true effects are,” Grieco said. “Originally, we thought that mosquitoes would pick up the chemical in the air and move away from the area. But now through some of our research, we’ve found that they impact on biting, mating and many other behaviors. They’re causing a disruption in the mosquito lifestyle, which has an impact on the disease.”Bernhard said researchers at Notre Dame have a history of working with infectious, neglected tropical diseases that goes back to the 1940s.“We believe that being a force for good in the world means that we need to have some of our programs be more applied and in-the-field,” Bernhard said. “It’s part of the bigger strategy to reach out and be involved in research that has an impact.”Tags: academic research, biology research, disease prevention, research grants
Pezer Won the Gold Medal at the European Winter Throwing Cup
Bosnia-Herzegovina’s young athlete Mesud Pezer won the gold medal in shot put in the category of young seniors (U-23) at European Cup Winter Throwing in Leiria (Portugal).In the competition of 19 competitors Pezer achieved result of 19.40 m, breaking his personal record and setting new overall national record in the category of young seniors.This young athlete is the national champion in junior category as well.Javelin thrower Dejan Mileusnić also performed at the European Cup Winter Throwing. He qualified for the competition with his score of 80.40 m as 11th among 23 registered participants.(Source: novovrijeme)
Extra games pay big dividends as LVR prepares for AA Field Hockey provincials
It’s always good to look on the brighter side of life.So when the L.V. Rogers Bombers suffered a crushing 1-0 loss to J. Lloyd Crowe Hawks in the final of the West Kootenay High School Girl’s Field Hockey Tournament, skipper Val Gibson took the positive approach.And the strategy paid off in spades as the Bombers not only qualified for the B.C. High School AA Girl’s Field Hockey Championships with Wild Card wins over Princess Margaret of Penticton and Surrey’s Southridge, but the players gains some valuable experience playing on a surface that will be identical to the provincial showdown.“The Wild Card games were a terrific chance for the Bombers to practice on the turf field and for the girls to gain some confidence,” Gibson said on the eve of the three-day AA tournament beginning Wednesday in West Vancouver.“It also allowed the girls to try moves that just do not work on grass.”LVR opened last week’s Wild Card tourney in Kelowna with a 2-0 win over Okanagan No. 2 Princess Margaret. Hailee Gerun and Jena Wheeldon provided the offence.The Bombers then dumped Fraser Valley No. 3 from Southridge by the same 2-0 score as Allie Zondervan and Chiara Chirico scored.Tara Yowek, a key to LVR’s success, backstopped the wins in goal.“Tara is very smart and very aggressive (and) manages the defence very well,” Gibson said of her star keeper.“She is fearless in goal but will need to control her emotions.”The wins power the Bombers to the tournament ranked ninth overall.LVR has been slotted into the four-team pool with Collingwood from the North Shore, Vancouver Island rep Shawnigan Lake Island and Little Flower Academy of Vancouver.Other players that must play well for LVR include midfielders Naomi Perkins, Hailee Gerun, Abbie Bourchier-Willans and Allie Zondervan along with snipers Emma Borhi, Jena Wheeldon, Lauren Walgren and Chiara Chirico.This is the second straight year LVR has qualified for the tournament after being shutout of the event since 2001.In 2012, the Bombers finished 10th after losing to Rossland in the final game of the tourney 2-1.
Half-time: Newcastle 0 QPR 0
Hard-working QPR went in goalless at half-time after a resolute defensive showing at St. James’ Park.Rangers keeper Rob Green comfortably denied Remy Cabella and twice kept out efforts from Ryan Taylor, while his back four kept the in-form Magpies at bay with blocks and headed clearances.At the other end, QPR fashioned some half chances of their own, with Charlie Austin firing at Tim Krul and Richard Dunne’s header forcing the Dutchman into a backpedalling save.Rangers were almost embarrassed early on when Steven Caulker, under pressure from Jack Colback, played a short backpass and Green’s clearance cannoned off the Newcastle midfielder and dropped wide of the post.Cabella was the first to test Green, with a low shot from 15 yards that the QPR keeper fielded without alarm.Rangers’ first flash of inspiration came from Austin, when he dispossessed Paul Dummett and then fired an angled shot across goal.Ryan Taylor almost marked his first Premier League start since March 2012 with a goal when he was picked out on the edge of the box by Cabella’s corner, but Green tipped his effort over the bar.Cabella and Taylor combined again a few minutes later but Green saved the latter’s shot. Sadly, Taylor later went off with an injury and was visibly upset that his return had been curtailed.As half-time approached, Austin shot straight at Krul while at the other end Daryl Janmaat volleyed wide.Krul was called into action when Dunne got his head to a Joey Barton corner, and as it looked like looping under the crossbar, the Dutchman tipped it over. QPR: Green, Onuoha, Caulker, Dunne, Yun, Barton, Henry, Sandro, Fer, Zamora, Austin.Subs: McCarthy, Traore, Phillips, Isla, Mutch, Kranjcar, Hoilett.Follow West London Sport on TwitterFind us on Facebook
Sarbanes-Oxley Ripples across Silicon Valley — Free Upgrades Gone?
Cnet reports that more high-profile resignations from startups like those in Silicon Valley are likely to follow. They also suggest that many startups will seek to stay private to stay clear of compliance requirements. Another alternative is for those companies to go public on foreign exchanges, and many new company listings have shifted to the UK.An interesting statistic is that while new listings in the UK are soaring, so is fraud. The British accounting firm BDO Stoy Hayward found that the reported instances of business fraud in the UK jumped 30 percent last year and that the value of the fraud reported jumped 40 percent.Consider also the ongoing scandal of backdating of stock options. The ability to do this has been diminished with the introduction of Sarbanes-Oxley. Options now need to be reported to the SEC within two business days of award. The whole backdating scandal would never have come to light had it not been for stricter SEC rules on executive pay disclosure and the work of academics who analyzed the public data and uncovered strong correlations between option grants and stock price.Now with Apple and Steve Jobs in the middle of the scandal, it is somewhat ironic they are invoking Sarbanes-Oxley as the reason for why they plan to charge for a software update. Apple will charge $1.99 for users of Core 2 Duo Intel Macs to use 802.11n WiFi hardware. Apple says “The nominal distribution fee for the 802.11n software is required in order for Apple to comply with generally accepted accounting principles for revenue recognition, which generally require that we charge for significant feature enhancements, such as 802.11n when added to previously purchased products”.If Apple’s interpretation of Sarbanes-Oxley holds then many or all software updates, whether they are service packs or bug fixes, may need to be for a fee to be legal. Are there any implications for Open Source software here? Probably not, but it’s likely that this will get a lot of public companies looking more closely at the language of their end-user license agreements (EULAs). Venture Capitalist and entrepreneur Jim Clark stepped down as chairman of the online photo service Shutterfly earlier this month because he said that Sarbanes-Oxley had “gone too far”. Clark said that because of Sarbanes-Oxley that he could not “Chair any committee due to the size of my holdings, because of the loan I once made to the company, not be on the governance committee, and it even dictates that some other board member must carry out the perfunctory duties of Chairman. What’s left is liability and constraints on stock transactions, neither of which excite me.” Five years since becoming law, high-tech Silicon Valley companies are now finding themselves running amuck with Sarbanes-Oxley Compliance regulations.Small companies have argued that Sarbanes-Oxley hits them disproportionately hard on their financial bottom lines. On Tuesday the Washington Post gives the example of no-revenue biotech companies being made to comply with the same accounting procedures of multibillion-dollar competitors, diverting money to accountants and lawyers that could better be spent in research and development.Treasury Secretary Paulson headed a committee that made recommendations in late 2006 that attempted to reduce some of the high costs of implementing Sarbanes-Oxley, especially for smaller companies. On the one hand, Paulson was criticized by the corporate governance group, the Council of Intstitutional Investors, for undermining the effectiveness of the original intent of the legislation.But the National Venture Capital Association, coming from the perspective of many small Silicon Valley startups, criticized Paulson for not going even further to help out small companies that have been affected by the compliance regulations. The group called it a “step backwards based on work and recommendations that have already been put forth.”
CWG scam: Delhi court to hear Suresh Kalmadi’s bail plea
A court in Delhi will on Thursday hear the bail petition of former Commonwealth Games (CWG) Organising Committee chairman Suresh Kalmadi in a corruption case related to the 2010 sporting event.The case relates to irregularities in the contract for Timing Scoring and Results (TRS) system for the CWG.The CBI named Kalmadi as the prime accused in its chargesheet on the TRS system scam. He was charged with conspiracy, forgery and under various provisions of the Prevention of Corruption Act.Kalmadi was arrested by the CBI last month in the CWG scam probe. But the former Congress leader claims he is innocent.
India cruise to seven-wicket win in first ODI against Bangladesh
Ajinkya Rahane anchored his innings to perfection in the company of comeback man Robin Uthappa and guided India to a comfortable seven-wicket victory in a rain-truncated first ODI against Bangladesh on Sunday.India’s Parvez Rasool, second right, celebrates the wicket of Bangladesh’s Anamul Haque, left, during their first one-day International cricket match in Dhaka on June 15, 2014. (AP Photo/A.M. Ahad)Chasing a target of 273 in 50 overs, India were cruising along at 100 for one in 16.4 overs when the heavens opened up leading to a nearly two-hour delay. This lead to a revised target of 150 in 26 overs courtesy of D/L method, which India achieved with seven balls to spare.The foundation was laid by Rahane, who scored 64 off 70 balls and shared a 99-run opening stand with Uthappa, who smashed a quickfire 50 off 44 balls.The delay affected the momentum and there were umpiring howlers from Bangladesh umpire Enamul Haque Moni. Ambati Rayudu (16) and Suresh Raina (15) were at the crease when the winning run was achieved.The decision that Uthappa got was a poor one as Shakib’s armer hit the bat first before hitting the pad.Nevertheless it was an impressive comeback for Uthappa in India colours after a break of six years. He seemed to carry his IPL form into international cricket, hitting three fours and as many sixes.The best shot was the one when he reached to the pitch of a flighted delivery from Shakib al Hasan to loft him effortlessly over extra cover. The other two were hit off left-arm spinner Abdur Razzak and medium pacer Ziaur Rahaman.advertisementWhile facing pacers Mashrafe Mortaza and Al-Amin, Uthappa showed full face of the bat.Rahane was also a delight to watch as he stepped out to lift Mortaza over extra cover and then pulled him towards mid-wicket for a boundary.He also used the sweep shot against Razzak.Cheteshwar Pujara (0) would consider himself unlucky as he got another howler from Moni, who adjudged him leg before off Shakib with ball hitting him on the thigh pads and clearly going above the stumps.Rahane finally completed his sixth ODI half centiry off 60 balls while Ambati Rayudu seemingly struggled against the slow bowlers before they reached home.
Microsoft revamps MSN in an attempt to increase appeal
Microsoft is planning to change the low-down image that MSN has fallen into. It quite recently revealed a major redesign to bring back the forgotten glory of MSN, keeping the idea of “mobile first, cloud first” at center.At the top of the new MSN landing page, there’s a large screen portion dedicated for alternate routes to Microsoft services like One Drive, Office 365 and Skype, in addition to well known social networking sites as Facebook and Twitter. Before long, the organization will present an assortment of MSN applications for Apple and Android gadgets that will work in sync with all of your gadgets, as well as store information in the cloud to be accessible anywhere.For instance, you will have the capacity to watch a rundown of stocks in MSN Money, games groups in MSN Sports, or cookbook-style food and beverages preparation methods – recipes. Microsoft stated that it wanted users to know that “those things will always be with you at your PC at work, on your iPad in the living room, or on your Android phone.”The new look also includes productivity tools like shopping lists and a savings calculator. There’s also a medical symptom checker and a 3D body explorer. In a blog post announcing the remake, Microsoft said the apps would launch “in coming months.” The MSN.com makeover itself is now available as a preview at preview.msn.com. It will roll it out in 55 markets worldwide in coming weeks. MSN.com has been around for nearly 20 years and still clocks more than 400 million monthly unique visitors, Microsoft says.advertisement
Morocco, US discuss ways to boost cooperation in field of energy
Rabat – Minister of Energy, Mines, Water and the Environment, Abdelkader Amara, held talks Monday in Rabat, with Ambassador of the United States of America in Morocco, Dwight L. Bush Sr., on ways to promote cooperation in the field of energy, including renewable energy.This meeting was an opportunity to discuss several topics including energy and ways to further promote the Moroccan-American cooperation in the energy field as well as the Free Trade agreement, Amara told the press.The two officials also discussed means to expand the prospects of this cooperation toward sub-Saharan countries, given the particular interest shown by HM King Mohammed VI and President Barack Obama toward the continent, he added, noting that Africa suffers from a shortage of equipment in terms of electrification and energy in general. In a similar statement, the American diplomat said he was “very happy” to be in Morocco, a “longtime friend,” deeming as “constructive” the talks with the Moroccan Minister.This meeting also discussed “the opportunities to work together,” Bush said, noting that they also focused on the commitment of His Majesty the King to expanding access to energy.
The Broncos New Quarterback Is Inexperienced But At Least Hes Not Peyton
By contrast, the average defending champ through 2015 returned a QB with 74.8 career starts and a lifetime AV of 66.5, meaning they were both pretty seasoned and pretty good. And that experience has traditionally been an advantage in the pursuit of a repeat Super Bowl bid. All else being equal, teams whose opening-day QBs have more career AV under their belt tend to perform better in the passing game. For instance, a simple regression would predict a 70-AV QB’s team to pass the ball with a half-standard deviation greater efficiency3According to Football Outsiders’ defense-adjusted value over average (DVOA) metric. — the equivalent of four-fifths of an extra win over a full season — than that of a zero-AV QB, while a more complex fit suggests the same edge in experience could be worth even more, as much as a full standard deviation of passing efficiency or 1.7 wins. When the Denver Broncos begin their title defense with Trevor Siemian under center on Sept. 8, they’ll be in a rare spot for reigning Super Bowl winners. Last year’s starting QB, Peyton Manning, retired in March, guaranteeing Denver would become only the fifth champ of the Super Bowl era1Since opening day of 1967, because there was no defending Super Bowl champ in Week 1 of the 1966 season. whose opening-day primary quarterback2For the purposes of this entire article, I’ll be referring to a team’s “primary QB” — the player who led the team in dropbacks in a game — as a proxy for its starter, since Pro-Football-Reference’s Game Finder doesn’t provide data on which QB started each game. during the next season was not the same signal-caller who led the way on Super Sunday.And even among that group of new QBs, Siemian is almost uniquely inexperienced. Assuming he ends up being Denver’s primary passer in Week 1, he’ll join another Bronco — Brian Griese, who replaced John Elway in 1999 — as the only opening-day primary QBs for a defending champion whose prior career featured both zero career starts and zero points of career Approximate Value (AV). So, given Siemian’s lack of experience (let alone his meager draft pedigree), we’d expect him to lead a passing attack that’s fairly lousy. But even if Siemian spearheads a passing offense with a DVOA index4Which sets DVOA on a common scale where 100 is league average and a standard deviation in either direction is 15 points. of 90, two-thirds of a standard deviation worse than NFL average — as the average zero-AV opening day starter has during the Super Bowl era — it would represent an improvement to the Broncos’ passing attack.Simply put, Denver won the Super Bowl last season in spite of its passing offense, not because of it. In terms of passing efficiency, the Broncos were an entire standard deviation worse than league average last season, which equated to the NFL’s eighth-most inefficient aerial attack. And Manning himself was awful, producing the worst season of any Super Bowl QB in history. His backup, Brock Osweiler, wasn’t great either, but if Siemian’s 2016 performance can mimic Osweiler’s more than Manning’s, the Broncos will still be better through the air than they were a year ago.And with a defense as dominant as the Broncos still possess, that might be enough to contend for another Super Bowl, even given Siemian’s historic inexperience under center.